Albumin orchestrates a natural host defence mechanism against mucormycosis. Νature, 2026
This study, led by Professor G. Chamilos with the participation of additional PRO-sCAP members, demonstrates that albumin acts as a central host defence mechanism against mucormycosis by transporting antifungal free fatty acids, opening new avenues for therapeutic or preventive interventions in a disease with extremely limited treatment options.
Epigenetic and metabolic regulation of macrophage responsiveness and memory. J Immunol. (2025)
This PRO-sCAP article highlights the role of histone modifications, DNA methylation, and metabolic reprogramming in shaping the inflammatory response, providing an important framework for understanding the pathogenesis of severe community-acquired pneumonia (sCAP).
Putrescine functions as a metabolic checkpoint in replication stress-induced senescence. Cell Mol Life Sci., 2025
Targeted analysis of single-cell transcriptomic data from COVID-19 pneumonia patients, with or without aspergillosis, reveals that senescent epithelial cells exhibit suppression of the putrescine biosynthesis pathway.
Easy Proteomics Sample Preparation: Technical Repeatability and Workflow Optimization Across 8 Biological Matrices in a New Core Facility Setting. Proteomics, 2025
This PRO-sCAP study presents a customized version of the SPEED protocol for proteomic analysis across multiple biological matrices, including bronchoalveolar lavage, enabling robust, repeatable, and scalable workflows.
Aspergillus fumigatus biology, immunopathogenicity and drug resistance. Nature Reviews Microbiology, 2025
This review summarizes current knowledge on Aspergillus fumigatus, focusing on mechanisms of pathogenicity, host immune interactions, and the growing challenge of antifungal resistance. Key gaps in diagnosis and treatment of invasive fungal infections are highlighted.
Future Prospects and Challenges in Mucormycosis Research. J Fungi. 2025
Opinion article proposing new approaches for improving the understanding of infections caused by emerging pathogens such as filamentous fungi.
IL-1beta expressing neutrophil extracellular traps in Legionella pneumophila infection. Front Immunol (2025).
Novel mechanisms of innate immune responses against L. pneumophila, with emphasis on the role of neutrophils.
